The role of reproductive hormones in epithelial ovarian carcinogenesis.

The effect of exosomes derived from human ovarian epithelial cancer cells on the secretion of AMH and Inhibin in granulosa cells

Exosomes are secreted by different types of cells and known as biological packages. Exosomes have significant role in intercellular communications and involved in the development and progression of various diseases such as cancer. Inhibin B and anti-mullerian hormone (AMH) are markers of granulosa cell tumors (GCT) and due to the role of exosomes in the progression of cancer, in this experiment...

Sulpiride-Induced Hyperprolactinemia in Mature Female Rats: Evidence for Alterations in The Reproductive System, Pituitary and Ovarian Hormones

Effects of Carthamus tinctorius L. on the ovarian histomorphology and the female reproductive hormones in mice

Objective: Carthamus tinctorius L. (Safflower) is a member of the asteraceae family which had been classified as a fertility regulator in the traditional medicine. The purpose of this study was to investigate its possible effects on the ovarian histomorphology and the levels of female reproductive hormones in the mice. Materials and Methods: Sixty adult female Balb/C mice were selected and rand...

Failure to Demonstrate the Role of High Risk Human Papilloma Virus in Epithelial Ovarian Cancer

Background and Aims: Ovarian cancer is one of most common causes of cancer related women's mortalities. Human papilloma virus is a known factor concerning cervical cancer but its role in causing ovarian cancer is not yet verified. A few studies also identified HPV DNA in ovarian carcinoma tissues. However, some studies did not detect HPV DNA in ovarian carcinoma tissues. In this articl...

AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice.

Although the amplified in breast cancer 1 (AIB1) coactivator is amplified and overexpressed in breast cancers, its role in mammary carcinogenesis remains unknown. We demonstrate that during mammary development and tumorigenesis, the elevation of AIB1 level and its nuclear localization correlate with normal and transformed mammary epithelial proliferation, whereas its lower expression and cytopl...